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Image Search Results
Journal: bioRxiv
Article Title: Virus-like particle displaying SARS-CoV-2 receptor binding domain elicits neutralizing antibodies and is protective in a challenge model
doi: 10.1101/2022.11.29.518404
Figure Lengend Snippet: Immunization with IVX-411 elicits higher neutralizing titers and a larger antigen-specific LLPC compartment than immunization with soluble protein. A) Female BALB/c mice were immunized IM with IVX-411, RBD-CompA, or S-2P formulated with or without MF59 on Day 0 and Day 21. Serum was collected on days 0, 20, 35, 63, 91, 119, and 154. Mice were sacrificed and bone marrow was collected on Day 154 for isolation of LLPCs (n = 10). (B) Serum neutralizing titers against the ancestral SARS-CoV-2 strain. (C) ELISpot measuring the frequency of RBD-specific LLPCs in the bone marrow. Dashed horizontal line represents the lower limit of quantitation. P-values were calculated in GraphPad Prism 9 using a Mann-Whitney test or a Kruskal-Wallis test followed by a Dunn’s multiple comparisons test. *, P< 0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001.
Article Snippet:
Techniques: Isolation, Enzyme-linked Immunospot, Quantitation Assay, MANN-WHITNEY